Set NoteTote to download files to the “Automatically Add To iTunes” directory on your Mac so all the files you download are added to your iTunes library.
Have NoteTote download files to your Dropbox folder — that way, you can upload any kind of file to your Dropbox while you’re on the go (something Dropbox's official iPhone and iPad apps don't support).
Tell NoteTote to download files to the directory that µTorrent is watching for new torrent files so all of your Linux ISOs and 100% legal, Creative Commons-licensed 1080p .mkv “videos of your cat” can start downloading to your home computer while you're still at the office.
Use Hazel to neatly sort the files NoteTote downloads and push them around your home network to where they need to be.
Get Prowl to send you a push notification when a file has finished downloading.
Use it right, and NoteTote can become a link in a very powerful chain.